Book

Description

Guillain-Barre´ syndrome (GBS) is an acute autoimmune poly-radicular neuropathy. Neutrophil-lymphocyte ratio (NLR) is a novel prognostic and inflammatory marker in patients with neurological diseases. GBS can stimulate the production of a high level of inflammation resulting in an increase in the NLR. It is assumed that, a relation exists between severity of GBS and increased NLR. The study was designed to observe the relation between NLR and the clinical severity in patients with GBS. This cross-sectional descriptive study was conducted at the department of Neurology & Medicine, Mymensingh Medical College & Hospital. Total 58 patients with GBS were enrolled according to the inclusion and exclusion criteria within 7 days of development of symptoms. All the participants were undergone general and neurological examination. The clinical diagnosis of GBS was done according to Ausbury and Cornblath’s diagnostic criteria; moreover clinical severity was done according to Hughes and Rees scale, Medical Research Council (MRC) grade, cranial nerve involvement & autonomic involvement. After measuring complete blood count, NLR was calculated by dividing neutrophil count to lymphocyte count. Data analysis was done on SPSS 23.0. Mean age of the GBS patients was 36.21±11.55 years. Among 58 respondents 70.69% (41) were male and 29.31% (17) were female. Most of the patients had a GBS severity score of 4 (62.07%) followed by 3 (27.59%) and 5 (10.34%). Hughes score had a positive correlation and MRC grade had a negative correlation with NLR. Severity of GBS was significantly associated with raised NLR. However further larger study is required before final comment.