Book

Description

Biophysical Insights into DNA–Peptide Assemblies: Structure, Flexibility, and Confinement Khadka B. Chhetri, PhD How do peptides shape the architecture and mechanics of DNA? How does phosphorylation influence DNA binding affinity and compaction? In this compelling volume, Dr. Khadka B. Chhetri explores the intricate world of DNA–peptide interactions through a biophysical lens, bridging computational modeling with molecular biology. From nanoscale structure and flexibility to confinement effects inside nanotubes and chromatin, this book synthesizes cutting-edge research on protamine-like peptides, phosphorylation effects, oxidized DNA behavior, and the mechanical properties of nucleic acids. Each chapter builds toward a deeper understanding of how DNA responds to its environment—and how that understanding can inform fields as diverse as gene therapy, nanotechnology, and chromatin biology. Accessible yet rigorous, this volume is essential reading for researchers and students in biophysics, molecular biology, computational science, and bioengineering.