The Role of MMPs and TIMPs in Regenerative Medicine
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In The Role of MMPs and TIMPs in Regenerative Medicine: From Pathological ECM Remodeling to Therapeutic Applications, the intricate balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is explored as a central driver of extracellular matrix (ECM) dynamics in health and disease. Bridging molecular biology and clinical innovation, this book examines how dysregulated ECM remodeling contributes to pathological conditions such as fibrosis, cancer progression, and chronic inflammation, while also highlighting how controlled modulation of MMP–TIMP activity can be harnessed for tissue repair and regeneration.
Through a combination of foundational science and translational perspectives, the book provides a comprehensive overview of ECM homeostasis, signaling pathways, and the regulatory networks governing proteolytic activity. It further delves into emerging therapeutic strategies, including biomaterial design, gene regulation approaches, and targeted pharmacological interventions aimed at restoring balance within the ECM microenvironment.
Designed for researchers, clinicians, and students in regenerative medicine, molecular biology, and biomedical engineering, this volume offers a timely synthesis of current knowledge and future directions in leveraging MMPs and TIMPs for innovative therapies in tissue regeneration and repair.