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Enterococci are common components of the microfloral community of human and other animals and are commonly found in soil, on plants, and in water. It is increasingly causing human infections and is being isolated from various clinical samples. This was a cross sectional study was conducted to determine the status and drug resistance pattern of enterococcus in a selected tertiary care hospital. Both descriptive and inferential statistics were used. Mean age of the respondents was 51.92±16.66. Mean monthly family income of the respondents was 28331.46±15704.84 BDT. Most of the specimen collected from urine (74.40%) followed by pus (9.60%), wound swab (4.80%), sputum (4.80%) and blood (4.0%). Two-third of the specimen (68.80%) showed significant presence of pus cell. Prevalence of Esccherichia coli was 36.6% followed by Klebsiella pneumonia (18.6%), Enterococcus species (9.8%), Pseudomonas species (7.4%), Enterobacter species (4.9%), Staphylococcous aerous (13.9%) and Proteus mirabilis (2.7%). About 87.6% amoxacillin was sensitive whereas 88.5% amoxiclave, 77.9% chloramphenicol, 96.5% gentamycin and imipenem, 87.6% nitrofurantoin, 99.1% liniazolid and 93.8% vanocomycin was sensitive. Prevalence of Enterococcus species in urine, pus and wound swab was 97.30%, 1.80% and 0.90%. Statistical significant association was found between age group and specimen (p=0.004<0.05).