Role of the Budding Yeast Protein, Chl1p, in Regulating Cell Cycle
$ 42.5
Description
Chl1p is a multifunctional protein. It has a role in chromosome segregation, also lethal with replication mutants. This book explains the additional role of Chl1p in preserving genome integrity upon DNA damage at different phases. The replication defects in the replication mutants accelerate by chl1, suggest a role of Chl1p in the maintenance of DNA integrity in replication mutants. As mcm2-1 and orc2-1 contains DNA damage, the sick interactions of chl1 with these mutations is due to the inability of the double mutants to repair that damaged DNA in replication mutants. In the presence of 0.035% MMS damage also, chl1 led to a loss in cell viability in S-phase, but the DNA damage checkpoint pathway remained fully active suggestive of Chl1p’s involvement in checkpoint-independent MMS induced DNA damage repair.