Phylogenomics and Pangenomics of Stenotrophomonas maltophilia Genomes
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Description
Stenotrophomonas maltophilia is a Gram-negative, aerobic bacillus considered an opportunistic pathogen found in a variety of environments, such as water, soil and the hospital environment. Treatment of infections caused by S. maltophilia is difficult because it is a resistant multi-drug bacterium that can acquire drug resistance through horizontal gene transfer and mutations. For these reasons, analyzes that make it possible to understand evolutionary and functional processes are of great importance. Thus, the aim of this study was to perform a comparative analysis between the complete genomes of the 22 strains of S. maltophilia. The results classified the pan genome as open according to Heap's law. Genes involved in the formation and maintenance of biofilms, flagella, membrane proteins and lipopolysaccharide have been identified. Thus, the recognition of these genes, which are related to the mechanisms of multidrug resistance, survival and virulence, in all 22 strains of S. maltophilia analyzed in this work, indicates that these are possible therapeutic targets and encourages further investigation, which could lead to more efficient treatments against infections caused by S. maltophilia.